Laboratory facilities

SPECTROMETERS

CCS175 Spectrometer (Thorlabs, Inc., USA)

Specifications:

• Fiber Optic Connector: SMA 905;
• Spectral Range: 500 – 1000 nm;
• Spectral Resolution: <0.6 nm FWHM;
• Signal-to-Noise Ratio: ≤2000:1;
• Integration Time: 10 µs – 60 s.

QEPRO-RAMAN Spectrometer (Ocean Optics Inc., USA)

Specifications:

• Fiber Optic Connector: SMA 905;
• Spectral Range: 785 – 935 nm;
• Raman Shift: 0 – 2800 cm-1;
• Optical Resolution: ~6 – 10 cm-1;
• Signal-to-Noise Ratio: 1000:1 (at full signal);
• Dynamic Range: 85000:1 for a single measurement;
• Integration Time: 8 ms – 60 min.

FLAME-T-VIS-NIR-ES Spectrometer (Ocean Optics Inc., USA)

Specifications:

• Fiber Optic Connector: SMA 905;
• Spectral Range: 350 – 1000 nm;
• Optical Resolution: ~1.5 nm FWHM;
• Signal-to-Noise Ratio: 300:1 (at full signal);
• Integration Time: 3.8 ms – 10 s.

DETECTORS

Balanced Photodetector PDB450A (Thorlabs, Inc., USA)

Specifications:

• Spectral Range: 320 – 1000 nm;
• Maximum Sensitivity: 0.53 A/W;
• Fiber Optic Connector: FC/PC.

Photodiode Amplifier PDA200C (Thorlabs, Inc., USA)

Specifications:

• Current Measurement Range: 100 na – 10 mA;
• Maximum Resolution: 10 pA;
• Photodiode Sensitivity: 0.05 – 2 A/W;
• Output Voltage Range: 0 – 10 V;
• Noise: ≤0.02%.

Photomultiplier Modules PMTSS (Thorlabs, Inc., USA)

Specifications:

• Spectral Range: 185 – 900 nm;
• Maximum Sensitivity: 105 mA/W.

Photomultiplier Modules PMTSS (Thorlabs, Inc., USA)

Specifications:

• Spectral Range: 280 – 630 nm;
• Maximum Sensitivity: 80 mA/W.

OPTICAL POWER METERS

Power Meter Console PM400 (Thorlabs, Inc., USA)

Specifications:

• Data Presentation Format: Numeric, Histogram, Trend Graph, Statistics;
• Analog Output: 3.5 mm Jack;
• Analog Output Voltage Range: 0 – 2 V;
• Auxiliary Input/Output: 2 x 7 pins;
• PC Connection Interface: Mini-B USB.

Photodiode Power Sensors S120VC (Thorlabs, Inc., USA)

Specifications:

• Spectral Range: 200 – 1100 nm;
• Power Range: 50 nW – 50 mW;
• Resolution: 1 nW.

Thermal Power Sensor Head S310c (Thorlabs, Inc., USA)

Specifications:

• Spectral Range: 0.19 – 25 µm;
• Power Range: 10 mW – 10 W;
• Resolution: 200 mW.

Integrating Sphere Photodiode Power Sensors S140C (Thorlabs, Inc., USA)

Specifications:

• Spectral Range: 350 – 1100 nm;
• Power Range: 1 µW – 500 mW;
• Resolution: 1 nW.

Integrating Sphere Photodiode Power Sensors S148C (Thorlabs, Inc., USA)

Specifications:

• Spectral Range: 1200 – 2500 nm;
• Power Range: 1 mW – 1000 mW;
• Resolution: 1 nW.

RADIATION SOURCES

785-LAB-ADJ Laser (Ocean Optics Inc., USA)

Specifications:

• Fiber Optic Connector: FC/PC;
• Stability: <3% from peak-to-peak in 8 hours;
• Output Power: >350 mW, adjustable;
• Wavelength: 785 ±0.3 nm;
• Spectral line Width: ~0.2 nm;
• Setting Time: <500 ms.

Fiber-Coupled LED M365FP1 (Thorlabs, Inc., USA)

Specifications:

• Wavelength: 365 nm;
• Typical Ø400 µm Core Fiber Output Powe: 15.5 mW;
• Fiber Optic Connector: SMA.

Fiber-Coupled LED M455F1 (Thorlabs, Inc., USA)

Specifications:

• Wavelength: 455 nm;
• Typical Ø400 µm Core Fiber Output Powe: 11.0 mW;
• Fiber Optic Connector: SMA.

LED M365LP1 (Thorlabs, Inc., USA)

Specifications:

• Wavelength: 365 nm;
• Typical Output Power: 1400 mW.

LED M365LP1 (Thorlabs, Inc., USA)

Specifications:

• Wavelength: 455 nm;
• Typical Output Power: 2100 mW.

LED M530L4 (Thorlabs, Inc., USA)

Specifications:

• Wavelength: 530 nm;
• Typical Output Power: 480 mW.

LED M490L4 (Thorlabs, Inc., USA)

Specifications:

• Wavelength: 490 nm;
• Typical Output Power: 240 mW.

Tungsten-Halogen Light Sources HL-2000-FHSA (Ocean Optics Inc., USA)

Specifications:

• Output Power: 8.8 mW;
• Spectral Range: 360 – 2400 nm;
• Color Temperature: 3000 K.

Tungsten-Halogen Light Source SLS201L/M (Thorlabs, Inc., USA)

Specifications:

• Output Power: 500 mW;
• Spectral range: 360 – 2600 nm;
• Color Temperature: 2796 K.

Laser Module LDM785 (Thorlabs, Inc., USA)

Specifications:

• Wavelength: 785 nm;
• Output Power: 20 mW.

Laser Diode Operation Starter Sets LTC56A/M (Thorlabs, Inc., USA)

Specifications:

• Current and Temperature Controllers;
• Aspheric Lens, AR: 350 – 700 nm;
• Modulation Frequency: 100 kHz-600 MHz.

Laser Diodes:

• L785H1 (Thorlabs, Inc., USA):
  • Wavelength: 785 nm;
  • Output Power: 200 mW.
• L450P1600MM (Thorlabs, Inc., USA):
  • Wavelength: 450 nm;
  • Output Power: 1600 mW.
• DL5146-101S (Thorlabs, Inc., USA):
  • Wavelength: 405 nm;
  • Output Power: 40 mW.

OBJECTIVES

Fixed Focal Length Objective MVL25M23 (Thorlabs, Inc., USA)

Specifications:

• Focal Length: 25 mm;
• Max Aperture: f/1.4;
• Min Object Distance: 200 mm;
• Camera Threading: C-mount.

Fixed Focal Length Objective MVL25TM23 (Thorlabs, Inc., USA)

Specifications:

• Focal Length: 25 mm;
• Max Aperture: f/1.8;
• Min Object Distance: 100 mm;
• Camera Threading: C-mount.

Mitutoyo Plan Apochromatic Objective MY5X-802 (Thorlabs, Inc., USA)

Specifications:

• Magnification*: 5X;
• Working Distance: 34mm;
• Effective Focal Length: 40 mm;
• Numeric Aperture: 0.14.

Mitutoyo Plan Apochromatic Objective MY20X-804 (Thorlabs, Inc., USA)

Specifications:

• Magnification*: 20X;
• Working Distance: 10 mm;
• Effective Focal Length: 10 mm;
• Numeric Aperture: 0.42.

*When used with an Objective with a Focal Length of 200 mm.

OTHER FACILITIES

Optical Beam Expander BE02-05-A (Thorlabs, Inc., USA)

Specifications:

• Expansion: 2X – 5X;
• Max Input Beam Diameter: 4.0 mm;
• AR Coating Range: 400 – 650 nm.

Tunable Filter KURIOS-VB1/M (Thorlabs, Inc., USA)

Specifications:

• Wavelength Range: 420 – 730 nm;
• Bandwidth (FWHM):
  • Narrow: 10 nm;
  • Medium: 18 nm;
  • Wide: 32 nm.
• Switching time:
  • Narrow: <230 ms;
  • Medium: <150 ms;
  • Wide: <100 ms.
• Minimum Incremental Step Size: 1 nm.

Electro-Optic Amplitude Modulator EO-AM-NR-C4 (Thorlabs, Inc., USA)

Specifications:

• Wavelength Range: 400 – 600 nm;
• Extinction Ratio: >10 dB;
• Clear Aperture: 2.0 mm.

High Voltage Amplifier HVA200 (Thorlabs, Inc., USA)

Specifications:

• Max Input Voltage Range: -10 –  10 V;
• Output Voltage: -200 – 200 V;
• Max Output Current: 100 mА;
• Slew Rate: 400 V/μs;
• Voltage Gain: -20 ± 2%;
• Output Noise: 1.5 mV.

Spectrophotometer UV-2600 (Shimadzu Corporation, Japan)

Specifications:

• Wavelength Range: 185 – 1400 nm;
• Spectral Bandwidth: 0.1; 0.2; 0.5; 1; 2 and 5 nm;
• Photometric System Design: Double Beam;
• Wavelength Scan Rate: 4000 – 0.5 nm/min;
• Wavelength Slew Rate: up to 14000 nm/min.

OPTICAL BIOMEDICAL DIAGNOSTICS FACILITIES

LAKK-02 (SPE “LAZMA” Ltd, Russia)

• 2 laser Doppler flowmetry (LDF) channels;

LAKK-OP (SPE “LAZMA” Ltd, Russia)

• LDF channel;
• Pulse oximetry channel.

Multifunctional Laser Non-Invasive Diagnostic System LAKK-M (SPE “LAZMA” Ltd, Russia)

• LDF channel;
• Fluorescence spectroscopy (FS) channel (fluorescence excitation wavelengths: 365, 450, 530, 650 nm);
• Pulse oximetry channel.

LAZMA Endoscopy (SPE “LAZMA” Ltd, Russia)

• LDF channel;
• FS channel (fluorescence excitation wavelengths: 365, 450 nm);
• External connection of optical fiber probes.

LAZMA D (SPE “LAZMA” Ltd, Russia)

• LDF channel;
• FS channel (fluorescence excitation wavelengths: 365, 450 nm).

LAZMA TEST (SPE “LAZMA” Ltd, Russia)

• Temperature range of the external unit: 10 – 45°С;
• Electrical stimulation device.

Portable Laser Analyzer of Blood Microcirculation "LAZMA PF" (SPE “LAZMA” Ltd, Russia)

• Four portable devices with LDF channels;
• Data transfer protocol: Bluetooth.

Portable Laser Analyzer of Blood Microcirculation "LAZMA PF" (SPE “LAZMA” Ltd, Russia)

• Four portable devices with LDF channels;
• FS channel (fluorescence excitation wavelength: 365 nm);
• Data transfer protocol: Bluetooth.

EXPERIMENTAL SYSTEMS OF R&D CENTER OF BIOMEDICAL PHOTONICS

Fine Needle Optical Biopsy System

Specifications:

• Fluorescence Excitation Wavelengths: 365, 450 nm;
• Broadband Source Wavelength Range: 360 – 2400 nm;
• Spectrometer Wavelength Range: 350 – 1000 nm;
• Opitcal Filters Cut-On Wavelengths: 400, 495 nm;
• Fiber Probe Diameter: 1 mm;
• Needle Probe Bevel: 20°;
• Optical Connectors: SMA 905, 4 pcs.

Fluorescence Lifetime Measurement System (Becker & Hickl GmbH, Germany)

Laser BDS-SM-375-FBC-101

Specifications:

• Wavelength: 375 nm;
• Repetition Rate: 20, 50, 80 MHz;
• Pulse Width (at average and maximum power, respectively): 30 mW – 90 ps, 60 mW – 300 ps.

Detectors HPM-100-40-CMOUNT

Specifications:

• Two detectors;
• Wavelength Range: 250 – 720 nm;
• Max. Quantum Efficiency: 45% at 500 nm.

Digital Laser Doppler Flowmetry System

• Number of Channels: 2 for variable, 2 for constant signal components;
• Sampling Frequency: 50 kHz/channel;
• Laser source power at the fiber end: 4 mW;
• Wavelength: 1064 nm.

Two-Channel Contact Thermometry Device

• Registration of skin temperature changes in combination with the LDF signal;
• Sensitivity: 0.05°С.

СELL PHYSIOLOGY AND PATHOLOGY LABORATORY FACILITIES

MICROSCOPES

Confocal Microscope ZEISS LSM 900 with Airyscan 2 (Carl Zeiss AG, Germany)

Specifications:

• Inverted stands;
• Objectives:
  • 63Х, Oil immersion, NA 1.4;
  • 20Х, NA 0.8;
  • 10Х, NA 0.3.
• Fluorescence Filters:
  • 410 – 440 nm;
  • 499 – 529 nm;
  • 607 – 677 nm;
  • 659 – 759 nm.
• Confocal Module:
  • Fluorescence excitation laser lines: 405, 488, 561, 640 nm;
  • Scanning Resolution: 32 х 1 – 6144 х 6144;
  • Max. scanning speed: 8 images/s.

Biological Microscope IX73Р1F (Olympus Corporation, Japan)

Specifications:

• Inverted stands;
• Objectives:
  • 40Х, NA 1.35;
  • 20Х, NA 0.8.
• Monochromator:
  • Wavelength Range: 300 – 800 nm;
  • Spectral Resolution: 0.5 nm;
  • Bandwidth: 0 – 30 nm.
• Dichroic mirrors:
  • 400 nm;
  • 510 nm;
  • 565 nm;
  • 4 bands (450, 513, 600, 680 nm);
  • 2 bands (500, 610 nm).
• CMOS camera:
  • Resolution: 3200 x 2200;
  • Max. Quantum Efficiency: 73%;
  • Max. Frame Rate: 50 FPS.

MICROBIOLOGICAL FACILITIES

Two Microbiological Safety Cabinets BMB-II-Laminar-S.-1.2 (LAMSYSTEMS CC, Russia)

Specifications:

• Air cleanliness class according to ISO 14644-1-2002: 5 ISO;
• Cabinet class according to ЕN 12469:2010: II;
• Air recirculation rate: ≈70%.

Oxygen Respiration Measurement System Oxytherm+R (Hansatech Instruments Ltd, UK)

Specifications:

• Temperature Range: 3 – 40°C (25°C ambient);
• Oxygen electrode type: Clark-type polarographic oxygen electrode disc;
• Oxygen Measuring Range: 0 – 100%;
• pH Measuring Range: 0 – 14.

Benchtop pH/mV Meter HI 2211-02 (Hanna Instruments Inc., USA)

Specifications:

• pH Range: -2.00 – 16.00; ±399.9 mV; ±2000 mV;
• pH Resolution: 0.01 pH; 0.1 mV; 1 mV;
• pH Accuracy: ±0.01 pH; ±0.2 mV (±399.9 mV); ±1 mV (±2000 mV);
• Temperature Range: -9.9 – 120°C.

Compact CO2 Incubator Midi 40 (Thermo Fisher Scientific Inc., USA)

Specifications:

• Chamber Volume: 39.6 L;
• Temperature Range: 5°C above ambient – 60°C;
• Temperature Uniformity: ±0.5 at 37°С;
• СО2 range: 0 – 20%.

CO2 Incubator С60 (Labotect GmbH, Germany)

Specifications:

• Chamber Volume: 60 L;
• Temperature Range: 27 – 42°С, starting 5°C above ambient;
• Temperature Stability: ±0.1°С;
• СО2 Range: 0 – 10%.

Freezer LGUex 1500 MediLine (Liebherr-Hausgeräte GmbH, Germany)

Specifications:

• Freezer Compartment Volume: 129 L;
• Temperature Range: -9 – -26°C.

Combination Lab Refrigerator/Freezer 263C-AEV-TS (Thermo Fisher Scientific Inc., USA)

Specifications:

• Temperature Range (Refrigerator): 1 – 11°C;
• Temperature Range (Freezer): -10 – -30°C;
• Refrigerator Volume: 159 L;
• Freezer Volume: 109 L.

Drying Chamber FED 53 (BINDER GmbH, Germany)

Specifications:

• Interior Volume: 60 L;
• Temperature Range: ambient temp + 10 – 300°C;
• Temperature Fluctuation at 150°C: 0.3°C.

Water Bath NB 5 (Nuve Sanayi Malzemeleri Imalat ve Tic., Turkey)

Specifications:

• Tank Volume: 4 L;
• Temperature Range: ambient temp + 5 – 99,9°C.

Microcentrifuge Microfuge 20 (Beckman Coulter, Inc., USA)

Specifications:

• Maximum Speed: 15000 rpm (20627 x g);
• Increased safety measurements with fixed angle rotor FA361.5;
• Temperature range: -10 – 40°С.

Analytical Balance VL-220C (SPE “GOSMETR” Ltd, Russia)

Specifications:

• Accuracy Class according to GOST R53228-2008: I special;
• Weighing Capacity: 220 g;
• Minimum Unit Mass: 0.5 mg;
• Readability: 0,0001 g;
• Measurement Error:
  • 0.5g – 500 g: ±50;
  • 500 g – 1100 g: ±100;
  • 200 g – 220 g: ±1.5.

Laboratory Balance VLTE-1100 (SPE “GOSMETR” Ltd, Russia)

Specifications:

• Accuracy Class according to GOST OIMLR76-1-2011: II high;
• Weighing Capacity: 1100 g;
• Minimum Unit Mass: 0.5 g;
• Readability: 0.01 g;
• Measurement Error:
  • 0.5g – 500 g: ±50;
  • 500 g – 1100 g: ±100.

Compact Balance EK-610i (A&D Company, Limited, Japan)

Specifications:

• Weighing Capacity: 600 g;
• Minimum Unit Mass: 0.5 g;
• Readability: 0.01 g.

The laboratory is equipped with optical and optomechanical components kits, fiber cables and probes for designing and assembling experimental setups and conducting research. We have several working places with optical tables, including the ones equipped with pneumatic vibration isolation systems.
There is an equipped workplace with soldering and measuring equipment for working with electronic units.

The laboratory of cell physiology and pathology is stocked with necessary equipment for storing, cultivating and working with cell cultures.