An advanced training program has been developed for research teams at the Cell Physiology and Pathology Laboratory

The Center for Continuous Professional Education and Professional Development created in 2018 in the Federal State Budget Educational Institution of Higher Education "Orel State University named after I.S. Turgenev" in its educational policy seeks to implement an effective model of designing additional professional programs, both demanded in the labor market of the region, and resulted from promising scientific research. Over three years, experience has been accumulated in implementing additional professional programs for scientific teams of employees who carry out scientific research and improve their professional skills.

The next step in the design of programs for scientific teams was made in the development of the advanced training program within the framework of the megagrant of the Government of the Russian Federation for state support of scientific research led by leading scientists in Russian educational institutions of higher professional education, scientific institutions of state academies of sciences and state scientific centers of the Russian Federation "Mitochondria as a Target in the Mechanism of Neurodegenerative Diseases" on the basis of the established in 2019 Cell Physiology and Pathology Laboratory.

The main area of research in the laboratory is the study of the mechanism of mitochondrial dysfunction in cellular models of neurodegenerative diseases.


In the framework of the developed professional development program "Confocal laser scanning microscopy in the practice of preclinical studies of drugs" (72 hours) trainees form additional professional competencies in the application of methods of modern microscopy in preclinical studies of drugs in vitro.


The listeners of this course are graduate students of higher medical, technical, chemical, biological, biotechnological education, as well as practicing specialists with higher education in the above fields, who are specialists of state and commercial institutions and organizations of various forms of ownership, performing microscopic studies of pharmacological activity of drugs within the scope of their professional activity.

From September 22 to October 06, 21 people are being trained in the program.


Students of the program in the process of practice-oriented training learn and master the methods and features of scientific research in vitro using the method of confocal microscopy. In practice they learn to use the method of confocal microscopy to develop plans and preclinical studies of drugs, interpret the data obtained in the course of studies, if necessary justify and plan the volume of additional studies.


As a result of the program students will acquire skills in developing protocols for preclinical studies of specific pharmacological activity of drugs using confocal microscopy; practical skills in preparing samples for studies by laser scanning confocal microscopy; practical skills in processing and interpretation of the obtained information using confocal microscopy.


The program is structured on a modular basis and includes two interrelated and interdependent sections. The first module is devoted to the study of the basics of laser scanning confocal microscopy. The second module involves practical skills in the application of confocal microscopy in medical and biological research.

The trainees of the advanced training program noted the high level of elaboration of the content of the main issues of the thematic plan. Depth of theoretical material presented in the field of confocal laser scanning microscopy and its reinforcement by the example of work with the confocal microscope ZEISS LSM 900 with the Airyscan 2 System contributed to the rapid consolidation of knowledge in practice. In addition, the practical module with the use of various cell lines allowed to work thoroughly on the skills of selecting the optimal parameters of the experimental setup, measurement modes, as well as their adjustment to the fluorescent probes used for correct obtaining information about the analyzed processes.